Aifm1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAifm1 ELISA Kit for Rat(Rattus norvegicus)

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Aifm1 (Gene name),

Apoptosis-inducing factor 1, mitochondrial (Protein name ), AIFM1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Aifm1(Aif;Pdcd8);

Protein name:

Apoptosis-inducing factor 1, mitochondrial;

Alternative:

Programmed cell death protein 8;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with XIAP. Interacts (via N-terminus) with EIF3G (via C-terminus).

Function:

Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis,and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

Subcellular Location:

Mitochondrion intermembrane space Mitochondrion inner membrane Cytoplasm Cytoplasm perinuclear region Nucleus Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.

Protein Attributes:

Sequence length:

612

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

612:

NEVAKLFNIH | ED

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00070

SMR:

Q9JM53

KEGG:

rno:83533

String:

Q9JM53

UniGene:

Rn.203165

Uniprot:

Q9JM53

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ELISA Kit for Rat Apoptosis-inducing factor 1, mitochondrial

Cat.:

E1064h

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96T

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ELISA Kit for Rat Apoptosis-inducing factor 1, mitochondrial

Cat.:

E1064r

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96T

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ELISA Kit for Rat Apoptosis-inducing factor 1, mitochondrial

Cat.:

E1064m

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CLIA Kit for Rat Apoptosis-inducing factor 1, mitochondrial

Cat.:

U1064r

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Looking for manual.

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Packing:

96T

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CLIA Kit for Rat Apoptosis-inducing factor 1, mitochondrial

Cat.:

U1064h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Rat Apoptosis-inducing factor 1, mitochondrial

Cat.:

U1064m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Apoptosis-inducing factor 1, mitochondrial

Cat.:

P1064Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Apoptosis-inducing factor 1, mitochondrial

Cat.:

P1064Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Apoptosis-inducing factor 1, mitochondrial

Cat.:

P1064Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Apoptosis-inducing factor 1, mitochondrial

Protein for Rat Apoptosis-inducing factor 1, mitochondrial

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning of rat apoptosis-inducing factor (AIF)."
Ohsakaya S. , Mihara K.
Submitted (2000-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

"Cloning and characterization of rat apoptosis-inducing factor: implications for DNA fragmentation in cerebral ischemia."
Cao G. , Sheng L. , Pei W. , Chen J.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Cerebellum.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Heart.
4.

Lubec G. , Kang S.U. , Lubec S.
Submitted (2007-09) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 378-386;IDENTIFICATION BY MASS SPECTROMETRY
strain: Sprague-Dawley.
tissue: Brain.

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